Least sedating tricyclic
In comparison research, this drug has proven to have less side effects than Amitriptyline, Imipramine, and Prozac, with comparable efficacy. Due to its slightly euphoric stimulant effects, word had quickly spread about the drug. It also has been documented as blocking activity of the neurotransmitter acetylcholine.
It is considered to work more quickly with fewer side effects than Amitriptyline and is regarded as being equal in terms of efficacy. Some believe that Butriptyline may act as a prodrug of Amitriptyline, with more favorable results. It is also considered a drug that can be used to treat hives and extensive itchiness. Additionally it may carry anticholinergic and antiadrenergic effects. Naturally, in overdose, they can be cardiotoxic, prolonging heart rhythms and increasing myocardial irritability.
Some hypothesize that affecting the mu-opioid receptor could be contributing to the antidepressant effect of the drug. Some suggest that it may generate similar responses to the drug Imipramine, but it may have less side effects specifically those that are anticholinergic. It is also believed to enhance the reuptake of serotonin.
Some believe that it generates responses similar to that of Imipramine, but it functions mostly by preventing reuptake of serotonin and norepinephrine. However, symptoms may take several hours to appear if a mixed overdose has caused delayed gastric emptying. This drug is associated with increases in risk of breast cancer for women and is considered genotoxic. These properties are often beneficial in antidepressants, especially with comorbid anxiety, as it provides a sedative effect.
In some cases it is used in European countries and South Asia. The properties of the drug suggest that it works by inhibiting the reuptake of serotonin and norepinephrine.
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